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High-dose B12, particularly intramuscular injections delivering 1,000 micrograms or more, appears more likely to trigger acne than standard dietary intake or lower-dose oral supplements

Generally, the benefits can last from several days to a few weeks, and regular maintenance injections may be recommended for sustained results

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When optimized and properly administered, B12 plays a crucial role in everything from red blood cell production to nerve function to metabolism

mRNA expression of ER decreased in the adipose tissue of obese women [70], and selective depletion of ER in adipocytes subsequently increased the adipocyte size and total adiposity in both sexes [71]